Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes

• Main Author: Michael Polymenis
• Format: Article
• Language: English
• Published: The Royal Society 2020-08-01
• Series: Open Biology
• Subjects: yeast; worms; flies; zebrafish; mouse; human
• Online Access: https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200114

Ribosomal proteins are highly conserved, many universally so among organisms. All ribosomal proteins are structural parts of the same molecular machine, the ribosome. However, when ribosomal proteins are mutated individually, they often lead to distinct and intriguing phenotypes, including specific human pathologies. This review is an attempt to collect and analyse all the reported phenotypes of each ribosomal protein mutant in several eukaryotes (Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Homo sapiens). These phenotypes were processed with unbiased computational approaches to reveal associations between different phenotypes and the contributions of individual ribosomal protein genes. An overview of gene expression changes in ribosomal protein mutants, with emphasis on ribosome profiling studies, is also presented. The available data point to patterns that may account for most of the observed phenotypes. The information presented here may also inform future studies about the molecular basis of the phenotypes that arise from mutations in ribosomal proteins.