Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma

• Main Authors: Jue Wang, Fen Wei Wang, George P. Hemstreet
• Format: Article
• Language: English
• Published: Hindawi Limited 2011-01-01
• Series: Prostate Cancer
• Online Access: http://dx.doi.org/10.1155/2011/216169
• ISSN: 2090-3111; 2090-312X

Objective. The aim of this study was to examine the epidemiology, natural history, treatment pattern, and predictors of long-term survival of signet ring prostate carcinoma (SRPC) patients based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database. Methods & Results. Between 1980 and 2004, a total of 93 patients with pathologically confirmed SRPC were identified. The mean age was 70±11 years old. 82.8% of the patients had poorly or undifferentiated histology grade. 13.9% patients presented with metastatic disease. The 1-, 3-, and 5-year cancer-specific survival rates were 94.6%, 89.6%, and 83.8%, respectively. Using multivariate Cox proportional hazard model, younger age (40–50 versus age >70 yrs, 𝑃=.01), advanced tumor stage (distant versus local/regional, 𝑃=.02), and earlier diagnosis year (before 1995 versus after 1995, 𝑃=.01) were predictors of worse cancer specific survival. Conclusions. Despite more aggressive cancer therapy, younger SRPC patients had a worse cancer specific survival. This information could be useful when counseling these patients and emphasizes the need for new strategies and molecular-based therapeutic approaches for younger patients with SRPC.