Autoregressive transitional ordinal model to test for treatment effect in neurological trials with complex endpoints

Autoregressive transitional ordinal model to test for treatment effect in neurological trials with complex endpoints

Abstract Background A number of potential therapeutic approaches for neurological disorders have failed to provide convincing evidence of efficacy, prompting pharmaceutical and health companies to discontinue their involvement in drug development. Limitations in the statistical analysis of complex e...

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Bibliographic Details
Main Authors: Lorenzo G. Tanadini, John D. Steeves, Armin Curt, Torsten Hothorn
Format: Article
Language:English
Published: BMC 2016-11-01
Series:BMC Medical Research Methodology
Subjects:
Upper extremity motor scores
Summed overall score
Multivariate ordinal endpoints
Proportional odds model
Statistical power
Spinal cord injury
Online Access:http://link.springer.com/article/10.1186/s12874-016-0251-y

Internet

http://link.springer.com/article/10.1186/s12874-016-0251-y

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