Levan in the developing of new colon-specific polymer material: evaluation of the permeability, moisture and thermal analyses in free films of Eudragit® FS 30 D = Levana no desenvolvimento de novo material polimérico cólon-específico: avaliação da permeabilidade, intumescimento e análises térmicas de filmes isolados de Eudragit® FS 30 D

Levan was used as agent in the synthesis of new colon-specific polymeric matrix together with Eudragit® FS 30 D. Eudragit® FS 30 D films incorporated with levan were made by casting process and characterized to: water vapour transmission, sweeling index, differential scanning calorimetry and thermog...

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Bibliographic Details
Main Authors: Osvaldo Albuquerque Cavalcanti, Maria Antonia Pedrine Colabone Celligoi, Fernando Cesar Bazani Cabral de Melo, Edgardo Alfonso Gomez Pineda, Leandro Freire dos Santos
Format: Article
Language:English
Published: Universidade Estadual de Maringá 2012-07-01
Series:Acta Scientiarum. Health Sciences
Subjects:
Online Access:http://www.periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/11729/pdf
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Summary:Levan was used as agent in the synthesis of new colon-specific polymeric matrix together with Eudragit® FS 30 D. Eudragit® FS 30 D films incorporated with levan were made by casting process and characterized to: water vapour transmission, sweeling index, differential scanning calorimetry and thermogravimetric. The levan increased the films permeability (p < 0.001) however did not influenced in the sweeling index of the formulations (p > 0.05). The thermal analyses of the films indicated a glass transition temperature approximate at 47°C and thermal decomposition at 400°C. The results indicated that there is potential for using such site-specificity blend as pharmaceutical coating material.<br><br>Levana foi utilizada na síntese de novo material polimérico cólon-específico conjuntamente com o Eudragit® FS 30 D. Filmes de Eudragit® FS 30 D aditivados de levana foram feitos pelo método de “casting process” e caracterizados quanto à transmissão de vapor de água, índice de intumescimento, calorimetria diferencial de varredura e termogravimetria. A levana aumentou a permeabilidade dos filmes (p < 0,001), entretanto não influenciou no índice de intumescimento das formulações (p > 0,05). As análises térmicas dos filmes indicaram uma temperatura de transição vítrea aproximada de 47°C e temperatura de decomposição de 400°C. Os resultados indicaram que há potencial de uso desta nova blenda sítio-específica como material de revestimento farmacêutico.
ISSN:1679-9291
1807-8648