Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2

Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2

Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera, biochemical and pathologi...

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Main Authors: Hong-Hui Li, Li-Jun Huo, Feng Zhao, Zhen-Ya Gao, Jun-Wen Zeng
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-02-01
Series:International Journal of Ophthalmology
Subjects:
bone morphogenetic protein-2
sclera
myopia
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949477/
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spelling doaj-7246135c2301492eb70593eca59d83842020-11-24T22:43:06ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-02-017115215610.3980/j.issn.2222-3959.2014.01.28Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2Hong-Hui Li0Li-Jun Huo1Feng Zhao2Zhen-Ya Gao3Jun-Wen Zeng4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera, biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949477/bone morphogenetic protein-2scleramyopiamyopia
collection DOAJ
language English
format Article
sources DOAJ
author Hong-Hui Li
Li-Jun Huo
Feng Zhao
Zhen-Ya Gao
Jun-Wen Zeng
spellingShingle Hong-Hui Li
Li-Jun Huo
Feng Zhao
Zhen-Ya Gao
Jun-Wen Zeng
Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
International Journal of Ophthalmology
bone morphogenetic protein-2
sclera
myopia
myopia
author_facet Hong-Hui Li
Li-Jun Huo
Feng Zhao
Zhen-Ya Gao
Jun-Wen Zeng
author_sort Hong-Hui Li
title Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
title_short Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
title_full Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
title_fullStr Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
title_full_unstemmed Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
title_sort regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series International Journal of Ophthalmology
issn 2222-3959
2227-4898
publishDate 2014-02-01
description Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera, biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.
topic bone morphogenetic protein-2
sclera
myopia
myopia
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949477/
work_keys_str_mv AT honghuili regulationofscleralfibroblastdifferentiationbybonemorphogeneticprotein2
AT lijunhuo regulationofscleralfibroblastdifferentiationbybonemorphogeneticprotein2
AT fengzhao regulationofscleralfibroblastdifferentiationbybonemorphogeneticprotein2
AT zhenyagao regulationofscleralfibroblastdifferentiationbybonemorphogeneticprotein2
AT junwenzeng regulationofscleralfibroblastdifferentiationbybonemorphogeneticprotein2
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