Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia

Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia

Cytoplasmic dynein 2 drives retrograde intraflagellar transport but little is known about its dynamics. Here the authors use fluorescence microscopy to track labelled dynein 2 inC. elegansat the single-molecule level and report diffusion at the ciliary base, and pausing and directional switches alon...

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Bibliographic Details
Main Authors: Jona Mijalkovic, Bram Prevo, Felix Oswald, Pierre Mangeol, Erwin J. G. Peterman
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14591
Description
Summary:Cytoplasmic dynein 2 drives retrograde intraflagellar transport but little is known about its dynamics. Here the authors use fluorescence microscopy to track labelled dynein 2 inC. elegansat the single-molecule level and report diffusion at the ciliary base, and pausing and directional switches along the cilium.
ISSN:2041-1723

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