Prevalence of the Prefoldin Subunit 5 Gene Deletion in Canine Mammary Tumors.

Prevalence of the Prefoldin Subunit 5 Gene Deletion in Canine Mammary Tumors.

A somatic deletion at the proximal end of canine chromosome 27 (CFA27) was recently reported in 50% of malignant mammary tumors. This region harbours the tumor suppressor gene prefoldin subunit 5 (PFDN5) and the deletion correlated with a higher Ki-67 score. PFDN5 has been described to repress c-MYC...

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Bibliographic Details
Main Authors: Silvia Hennecke, Julia Beck, Kirsten Bornemann-Kolatzki, Stephan Neumann, Hugo Murua Escobar, Ingo Nolte, Susanne Conradine Hammer, Marion Hewicker-Trautwein, Johannes Junginger, Franz-Josef Kaup, Bertram Brenig, Ekkehard Schütz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4489437?pdf=render

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