Characterization of high-H2O2-tolerant bacterial cytochrome P450 CYP105D18: insights into papaverine N-oxidation

Characterization of high-H2O2-tolerant bacterial cytochrome P450 CYP105D18: insights into papaverine N-oxidation

The bacterial CYP105 family is involved in secondary metabolite biosynthetic pathways and plays essential roles in the biotransformation of xenobiotics. This study investigates the newly identified H2O2-mediated CYP105D18 from Streptomyces laurentii as the first bacterial CYP for N-oxidation. The ca...

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Bibliographic Details
Main Authors: Bashu Dev Pardhe, Hackwon Do, Chang-Sook Jeong, Ki-Hwa Kim, Jun Hyuck Lee, Tae-Jin Oh
Format: Article
Language:English
Published: International Union of Crystallography 2021-07-01
Series:IUCrJ
Subjects:
cyp105d18
papaverine n-oxide
h2o2 tolerance
streptomyces laurentii
enzyme mechanisms
crystal morphology
co-crystals
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252521005522

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