The extent of coronary stenosis and the level of antibodies to atherogenic lipoproteins in patients with coronary heart disease

• Main Authors: Soreyya Asafovna Urazgil'deeva, Aleksandr Yur'evich Titkov, Lyubov' Vasil'evna Vasina, Viktoriya Vital'evna Tsaregorodtseva, Viktor Savel'evich Gurevich, S A Urazgildeeva, A Yu Titkov, L V Vasina, V V Tsaregorodtseva, V S Gurevich
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2011-09-01
• Series: Терапевтический архив
• Subjects: atherosclerosis; ischemic heart disease; antibodies to oxidized low density lipoproteins; extent of coronary stenosis
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/30887

Aim. To study association between the level of antibodies to oxidized low-density lipoproteins (anti-OLDL) and the extent of coronary stenosis (CS) in patients with coronary heart disease (CHD). Material and methods. Sixty CHD patients were examined for titer of anti-OLDL, levels of total cholesterol (TC), LDLP cholesterol, HDLP cholesterol, triglycerides. Selective coronarography (SC) was made on demand. Results. Elevated titer of anti-OLDL was found only in 12 examinees. It was significantly lower in CHD women than in men. No significant differences by anti-OLDL were found in CHD patients with and without significant risk factors. SC registered in all CHD examinees local stenosis of different severity. Stenosis in 3 coronary arteries was detected in 31 cases, in 2 coronary arteries - in 14, in 1 coronary artery - in 15 patients, most frequently the affection was located in the diagonal branch of the left coronary artery. Stenosis of the left coronary artery trunk was diagnosed in one case. The correlation analysis revealed a strongly significant positive correlation between content of anti-OLDL and the degree of CS. Conclusion. The level of anti-OLDL in CHD patients directly correlates with the degree of CS and is a marker of coronary atherosclerosis severity.