A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies

A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies

Background: The limited diagnostic accuracy of biomarkers in children at risk of a serious bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed to evaluate the diagnostic performance of a new classification algorithm for biomarker discovery in children at risk...

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Main Authors: Ruud G. Nijman, Rianne Oostenbrink, Henriette A. Moll, Climent Casals-Pascual, Ulrich von Both, Aubrey Cunnington, Tisham De, Irini Eleftheriou, Marieke Emonts, Colin Fink, Michiel van der Flier, Ronald de Groot, Myrsini Kaforou, Benno Kohlmaier, Taco W. Kuijpers, Emma Lim, Ian K. Maconochie, Stephane Paulus, Federico Martinon-Torres, Marko Pokorn, Sam T. Romaine, Irene Rivero Calle, Luregn J. Schlapbach, Frank J. Smit, Maria Tsolia, Effua Usuf, Victoria J. Wright, Shunmay Yeung, Dace Zavadska, Werner Zenz, Michael Levin, Jethro A. Herberg, Enitan D. Carrol, The PERFORM consortium (Personalized Risk assessment in febrile children to optimize Real-life Management across the European Union)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pediatrics
Subjects:
serious bacterial infection
children
biomarkers
sepsis
clinical phenotypes
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.688272/full

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