Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its sele...
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MDPI AG
2011-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/6/4748/ |
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doaj-71ebb71de2c24fa3b977005a3867e95f2020-11-24T20:57:11ZengMDPI AGMolecules1420-30492011-06-011664748476310.3390/molecules16064748Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid DerivativesShaorong WangWeishuo FangA hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study.http://www.mdpi.com/1420-3049/16/6/4748/oleanolic aciddual linkersolid phase synthesisanalytical construct |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shaorong Wang Weishuo Fang |
| spellingShingle |
Shaorong Wang Weishuo Fang Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives Molecules oleanolic acid dual linker solid phase synthesis analytical construct |
| author_facet |
Shaorong Wang Weishuo Fang |
| author_sort |
Shaorong Wang |
| title |
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
| title_short |
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
| title_full |
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
| title_fullStr |
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
| title_full_unstemmed |
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
| title_sort |
design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2011-06-01 |
| description |
A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study. |
| topic |
oleanolic acid dual linker solid phase synthesis analytical construct |
| url |
http://www.mdpi.com/1420-3049/16/6/4748/ |
| work_keys_str_mv |
AT shaorongwang designandsynthesisofaduallinkerforsolidphasesynthesisofoleanolicacidderivatives AT weishuofang designandsynthesisofaduallinkerforsolidphasesynthesisofoleanolicacidderivatives |
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1716788568384339968 |