GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition

Objective: Idiopathic pulmonary fibrosis is an irreversible and progressive fibrotic lung disease that leads to declines in pulmonary function and, eventually, respiratory failure and has no effective treatment. Gly-His-Lys (GHK) is a tripeptide involved in the processes of tissue regeneration and w...

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Bibliographic Details
Main Authors: Xiao-Ming Zhou, Gui-Liang Wang, Xiao-Bo Wang, Li Liu, Qin Zhang, Yan Yin, Qiu-Yue Wang, Jian Kang, Gang Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
GHK
TGF-β1
pulmonary fibrosis
epithelial-to-mesenchymal transition
Smad
collagen
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00904/full

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