Differential role of CSF alpha-synuclein species, tau and Aβ42 in Parkinson’s Disease

Differential role of CSF alpha-synuclein species, tau and Aβ42 in Parkinson’s Disease

There is a great interest in developing cerebrospinal fluid (CSF) biomarkers for diagnosis and prognosis of Parkinson’s disease (PD). CSF alpha synuclein (α-syn) species, namely total and oligomeric α-syn (t-α-syn and o-α-syn), have shown to be of help for PD diagnosis. Preliminary evidences show th...

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Bibliographic Details
Main Authors: Lucilla eParnetti, Lucia eFarotti, Paolo eEusebi, Davide eChiasserini, Claudia eDe Carlo, David eGiannandrea, Nicola eSalvadori, Viviana eLisetti, Nicola eTambasco, Aroldo eRossi, Nour K Majbour, Shiji eVarghese, Omar eEl-Agnaf, Paolo eCalabresi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
cognitive impairment
alpha synuclein
cerebrospinal fluid biomarkers
total tau
phosphorylated tau
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00053/full

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