Effect of Usnic Acid on Osteoclastogenic Activity

• Main Authors: Kwang-Jin Kim, Min-Hye Jeong, Yongjin Lee, Sue-Jeong Hwang, Han-Byeol Shin, Jae-Seoun Hur, Young-Jin Son
• Format: Article
• Language: English
• Published: MDPI AG 2018-10-01
• Series: Journal of Clinical Medicine
• Subjects: bone; osteoporosis; osteoclast; usnic acid; NFATc1
• Online Access: http://www.mdpi.com/2077-0383/7/10/345

Osteoclasts are the only cells that can resorb bone and they are produced from monocytes/macrophages in the presence of M-CSF and RANKL and are activated in vivo by an immune response. Usnic acid is a secondary metabolite of lichen and has a unique dibenzofuran skeleton. It has been used for years in cosmetics, fragrances, and traditional medicines. It has a wide range of bioactivities, including anti-inflammatory, anti-bacterial, anti-cancer, anti-viral, and so on. However, the anti-osteoclastogenic activity of usnic acid has not been reported yet. In this study, we investigated whether usnic acid could affect RANKL-mediated osteoclastogenesis. Usnic acid significantly inhibited RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1, a master regulator of osteoclastogenesis. In addition, it prevented lipopolysaccharides (LPS)-induced bone erosion in mice. Taken together, our results suggest that usnic acid might be a potential candidate for the treatment of osteoporosis.