Increased neutrophil–lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification

• Main Authors: Takayuki Miura, Hideo Ohtsuka, Takeshi Aoki, Shuichi Aoki, Tatsuo Hata, Tatsuyuki Takadate, Shimpei Maeda, Kyohei Ariake, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Fumiyoshi Fujishima, Takashi Kamei, Hironobu Sasano, Michiaki Unno
• Format: Article
• Language: English
• Published: BMC 2021-03-01
• Series: BMC Surgery
• Subjects: Neutrophil–lymphocyte ratio (NLR); Pancreatic neuroendocrine neoplasm (PanNEN); Systemic immune-inflammatory marker
• Online Access: https://doi.org/10.1186/s12893-021-01178-3

Abstract Background The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed the ability to predict the recurrence of such markers after curative resection in patients with these neoplasms. Methods Circulating/systemic neutrophil–lymphocyte, monocyte–lymphocyte, platelet–lymphocyte, and platelet–white cell ratios were evaluated in 120 patients who underwent curative resection for well-differentiated pancreatic neuroendocrine neoplasms without synchronous distant metastasis between 2001 and 2018. Recurrence-free-survival and overall survival were compared using Kaplan–Meier analysis and log-rank tests. Univariate or multivariate analyses, using a Cox proportional hazards model, were used to calculate hazard ratios with 95% confidence intervals. Results Univariate analysis demonstrated that preoperative neutrophil–lymphocyte ratio, tumor size, European Neuroendocrine Tumor Society TMN classification, 2017 World Health Organization classification, and venous invasion were associated with recurrence. The optimal preoperative neutrophil–lymphocyte ratio cut-off value was 2.62, based on receiver operating characteristic curve analysis. In multivariate analysis, a higher preoperative neutrophil–lymphocyte ratio (HR = 3.49 95% CI 1.05–11.7; P = 0.042) and 2017 World Health Organization classification (HR = 8.81, 95% CI 1.46–168.2; P = 0.015) were independent recurrence predictors. Conclusions The circulating/systemic neutrophil–lymphocyte ratio is a useful and convenient preoperative prognostic marker of recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification.