SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
The onset of mammalian puberty is sensitive to metabolic changes and nutritional status, but the mechanisms underlying this phenomenon are poorly understood. Here the authors show that the epigenetic regulator of transcription, SIRT1, mediates the effects of under and overnutrition on pubertal timin...
Full description
Bibliographic Details
| Main Authors: |
M. J. Vazquez,
C. A. Toro,
J. M. Castellano,
F. Ruiz-Pino,
J. Roa,
D. Beiroa,
V. Heras,
I. Velasco,
C. Dieguez,
L. Pinilla,
F. Gaytan,
R. Nogueiras,
M. A. Bosch,
O. K. Rønnekleiv,
A. Lomniczi,
S. R. Ojeda,
M. Tena-Sempere |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2018-10-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-018-06459-9
|
|---|
