Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication

Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation—cons...

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Main Authors:	Rossella Gratton, Almerinda Agrelli, Paola Maura Tricarico, Lucas Brandão, Sergio Crovella
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Series:	International Journal of Molecular Sciences
Subjects:	Zika virus autophagy Akt-mTOR innate immunity therapeutic targets
Online Access:	https://www.mdpi.com/1422-0067/20/5/1048

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spelling	doaj-71bfab847be94833a4bb596cc2b010db2020-11-24T21:59:12ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-02-01205104810.3390/ijms20051048ijms20051048Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral ReplicationRossella Gratton0Almerinda Agrelli1Paola Maura Tricarico2Lucas Brandão3Sergio Crovella4Department of Advanced Diagnostics, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, ItalyLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235—Cidade Universitária, 50670-901 Recife, BrazilDepartment of Advanced Diagnostics, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, ItalyDepartment of Pathology, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235—Cidade Universitária, 50670-901 Recife, BrazilDepartment of Advanced Diagnostics, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, ItalyZika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation—considered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.https://www.mdpi.com/1422-0067/20/5/1048Zika virusautophagyAkt-mTORinnate immunitytherapeutic targets
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rossella Gratton Almerinda Agrelli Paola Maura Tricarico Lucas Brandão Sergio Crovella
spellingShingle	Rossella Gratton Almerinda Agrelli Paola Maura Tricarico Lucas Brandão Sergio Crovella Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication International Journal of Molecular Sciences Zika virus autophagy Akt-mTOR innate immunity therapeutic targets
author_facet	Rossella Gratton Almerinda Agrelli Paola Maura Tricarico Lucas Brandão Sergio Crovella
author_sort	Rossella Gratton
title	Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
title_short	Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
title_full	Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
title_fullStr	Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
title_full_unstemmed	Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
title_sort	autophagy in zika virus infection: a possible therapeutic target to counteract viral replication
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2019-02-01
description	Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation—considered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.
topic	Zika virus autophagy Akt-mTOR innate immunity therapeutic targets
url	https://www.mdpi.com/1422-0067/20/5/1048
work_keys_str_mv	AT rossellagratton autophagyinzikavirusinfectionapossibletherapeutictargettocounteractviralreplication AT almerindaagrelli autophagyinzikavirusinfectionapossibletherapeutictargettocounteractviralreplication AT paolamauratricarico autophagyinzikavirusinfectionapossibletherapeutictargettocounteractviralreplication AT lucasbrandao autophagyinzikavirusinfectionapossibletherapeutictargettocounteractviralreplication AT sergiocrovella autophagyinzikavirusinfectionapossibletherapeutictargettocounteractviralreplication
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Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication

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