Pathological Neuroinflammatory Conversion of Reactive Astrocytes Is Induced by Microglia and Involves Chromatin Remodeling

Pathological Neuroinflammatory Conversion of Reactive Astrocytes Is Induced by Microglia and Involves Chromatin Remodeling

Following brain injury or in neurodegenerative diseases, astrocytes become reactive and may suffer pathological remodeling, features of which are the loss of their homeostatic functions and a pro-inflammatory gain of function that facilitates neurodegeneration. Pharmacological intervention to modula...

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Bibliographic Details
Main Authors: Alejandro Villarreal, Camila Vidos, Matías Monteverde Busso, María Belén Cieri, Alberto Javier Ramos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
neuroinflammation
reactive astrogliosis
epigenetics
NF-κB
microglia–astrocyte crosstalk
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.689346/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.689346/full

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