A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosac...

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Main Authors: Vincent Denavit, Danny Lainé, Jacob St-Gelais, Paul A. Johnson, Denis Giguère
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06901-y
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spelling doaj-71b3d4d6b81340a39a931d5a0fa208432021-05-11T09:54:50ZengNature Publishing GroupNature Communications2041-17232018-11-019111110.1038/s41467-018-06901-yA Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydratesVincent Denavit0Danny Lainé1Jacob St-Gelais2Paul A. Johnson3Denis Giguère4Département de chimie, 1045 av. De la Médecine, Université Laval PROTEO, RQRMDépartement de chimie, 1045 av. De la Médecine, Université Laval PROTEO, RQRMDépartement de chimie, 1045 av. De la Médecine, Université Laval PROTEO, RQRMDépartement de chimie, 1045 av. De la Médecine, Université Laval PROTEO, RQRMDépartement de chimie, 1045 av. De la Médecine, Université Laval PROTEO, RQRMPolyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively.https://doi.org/10.1038/s41467-018-06901-y
collection DOAJ
language English
format Article
sources DOAJ
author Vincent Denavit
Danny Lainé
Jacob St-Gelais
Paul A. Johnson
Denis Giguère
spellingShingle Vincent Denavit
Danny Lainé
Jacob St-Gelais
Paul A. Johnson
Denis Giguère
A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
Nature Communications
author_facet Vincent Denavit
Danny Lainé
Jacob St-Gelais
Paul A. Johnson
Denis Giguère
author_sort Vincent Denavit
title A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
title_short A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
title_full A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
title_fullStr A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
title_full_unstemmed A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
title_sort chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively.
url https://doi.org/10.1038/s41467-018-06901-y
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