Leukocyte Mitochondrial DNA Alteration in Systemic Lupus Erythematosus and Its Relevance to the Susceptibility to Lupus Nephritis

Leukocyte Mitochondrial DNA Alteration in Systemic Lupus Erythematosus and Its Relevance to the Susceptibility to Lupus Nephritis

The role of mitochondrial DNA (mtDNA) alterations in the pathophysiology of systemic lupus erythematosus (SLE) remains unclear. We investigated sequence variations in the D310 region and copy number change of mtDNA in 85 SLE patients and 45 normal subjects. Leukocyte DNA and RNA were extracted from...

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Bibliographic Details
Main Authors: Yau-Huei Wei, Chang-Youh Tsai, Hsien-Tzung Liao, Wei-Sheng Chen, Chen-Sung Lin, Hui-Ting Lee
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:International Journal of Molecular Sciences
Subjects:
systemic lupus erythematosus
mitochondrial DNA
copy number
D310 sequence variation
heteroplasmy
Online Access:http://www.mdpi.com/1422-0067/13/7/8853

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