Siderophore production by uropathogenic <i> <i><i><i>Escherichia</i></i></i> coli</i>

• Main Author: Vagrali Manjula
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2009-01-01
• Series: Indian Journal of Pathology and Microbiology
• Subjects: <i>Escherichia coli</i>; siderophore; uropathogenic
• Online Access: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=1;spage=126;epage=127;aulast=Vagrali

Urinary tract infection (UTI) is one of the most frequently encountered problems in ambulatory medicine. The present study was designed to determine siderophore production as the urovirulence factor of <i>Escherichia coli</i> isolated from the patients of UTI. A total of 160 strains of <i>E. coli</i> isolated from urine of patients with clinically diagnosed UTI were included in the study and 50 fecal isolates of <i>E. coli</i>, siderophore production was seen in 156 (97.5&#x0025;). In 50 fecal isolates, siderophore production was seen in 2 (4&#x0025;). Siderophore production has been shown to be more frequent in E. coli from patients with UTI, than in fecal isolates. The results suggest that siderophore production positive strains can be considered as UPEC. Thus, although a great deal has been learned regarding <i>E. coli</i> virulence mechanisms in UTI, much remains to be learned and the practical application of our growing understanding of <i>E. coli</i> virulence factors to the prevention and treatment of UTI has to be continued.