Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR

Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR

Abstract Background Patients with metastatic colorectal cancer can benefit from anti-EGFR therapy, such as cetuximab and panitumumab. However, colorectal cancers harboring constitutive activating mutations in KRAS, NRAS and BRAF genes are not responsive to anti-EGFR therapy. To select patients for a...

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Bibliographic Details
Main Authors: Yuki Nagakubo, Yosuke Hirotsu, Kenji Amemiya, Toshio Oyama, Hitoshi Mochizuki, Masao Omata
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Medical Genomics
Subjects:
KRAS
NRAS
BRAF
Colorectal cancer
BNA
Online Access:http://link.springer.com/article/10.1186/s12920-019-0610-8

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http://link.springer.com/article/10.1186/s12920-019-0610-8

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