Localized nasal cavity, sinus, and massive bilateral orbital involvement by human T cell leukemia virus 1 adult T cell lymphoma, with epidermal hypertrophy due to mite infestation

• Main Authors: Albert S. Braverman, Helen Durkin, Kathleen Laveaux, Constantine A. Axiotis
• Format: Article
• Language: English
• Published: SAGE Publishing 2010-12-01
• Series: Rare Tumors
• Subjects: Oncology: HTLV; lymphoma
• Online Access: http://www.pagepress.org/journals/index.php/rt/article/view/1913

<p class="MsoNormal" style="margin: 0in 0in 0pt;"><span style="font-family: 'Times New Roman';"><span style="font-size: small;"><p class="MsoNormal" style="margin: 0in 0in 0pt;">HTLV1 adult T cell lymphoma occurs tends to be widely disseminated and aggressive, with only brief responses to chemotherapy. Aside from cervical adenopathy, involvement of head and neck structures is uncommon and orbital involvement rare. </p><p class="MsoNormal" style="margin: 0in 0in 0pt;">We report a case of nasal cavity HTLV lymphoma with massive bilateral orbital involvement and proptosis, resulting in complete left and partial right eye amaurosis. No other sites of disease were found. Response to chemotherapy was rapid and complete, with almost complete restoration of vision and oculo-motor function; the patient has remained in remission for one year. An associated problem was striking bilateral hypertrophic, hyperkeratotic eyelid and breast lesions due to mite infestation. </p></span></span></p>