An Alpha Fetoprotein Producing Gastric Tumor with Yolk Sac, Hepatoid and Papillary Adenocarcinoma Components

• Main Authors: Archana Lakshmanan, Ann Kurian, Annapurneswari Subramanyan, Ayyappan Srinivasan
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2017-09-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: gastric carcinoma; stomach; tumour marker
• Online Access: https://jcdr.net/articles/PDF/10546/29454_CE[Ra]_F(Sh)_PF1(PG_GG)_PFA(SY_GG).pdf

Alpha Fetoprotein (AFP) producing gastric carcinomas are very rare and have unique clinicopathological features and an extremely poor prognosis. Here, we report a case of AFP producing gastric carcinoma with three distinct histomorphologic patterns such as yolk sac like, hepatoid, tubular and papillary adenocarcinoma components. The uniqueness of this case is absence of metastases and associated findings such as fundic gland polyposis with varying degrees of dysplasia, gastric and duodenal well differentiated neuroendocrine tumour and rectal ganglioneuroma. The patient is symptom free as of two and half year’s postoperative period. AFP producing gastric tumours although rare, need to be identified as it is known to carry poor prognosis.