Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor

Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor

We report a rare subtype of adult cystic granulosa cell tumor (AGCT) characterized by elevated anti-Mullerian hormone and hyperandrogenism. A 35-year-old woman with primary infertility, hyperandrogenism, and irregular menses who was previously diagnosed with polycystic ovarian syndrome was diagnosed...

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Main Authors: Hongbin Chi, Ning Huang, Huamao Liang, Rong Li, Congrong Liu, Jie Qiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
anti-Mullerian hormone
granulosa cell tumor
hyperandrogenism
infertility
ovarian cyst
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.641166/full
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spelling doaj-7196afab00ed48ba82a5f02cafb975092021-03-22T06:37:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.641166641166Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell TumorHongbin Chi0Ning Huang1Huamao Liang2Rong Li3Congrong Liu4Jie Qiao5Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaDepartment of Pathology, Peking University Third Hospital, Beijing, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaWe report a rare subtype of adult cystic granulosa cell tumor (AGCT) characterized by elevated anti-Mullerian hormone and hyperandrogenism. A 35-year-old woman with primary infertility, hyperandrogenism, and irregular menses who was previously diagnosed with polycystic ovarian syndrome was diagnosed with AGCT based on histopathological examination and FOXL2 genetic test after laparoscopy. Due to fertility aspirations, she underwent controlled ovarian stimulation followed by embryo cryopreservation before salpingo-oophorectomy, and two embryos were frozen-thawed and transferred after surgery. A healthy female infant was delivered at 40 weeks’ gestation. Cystic granulosa cell tumors should be considered a differential diagnosis in patients with persistent ovarian cysts and hyperandrogenism. Younger patients with AGCT with fertility goals should consider active assisted reproduction measures to preserve fertility before treatment for AGCT.https://www.frontiersin.org/articles/10.3389/fonc.2021.641166/fullanti-Mullerian hormonegranulosa cell tumorhyperandrogenisminfertilityovarian cyst
collection DOAJ
language English
format Article
sources DOAJ
author Hongbin Chi
Ning Huang
Huamao Liang
Rong Li
Congrong Liu
Jie Qiao
spellingShingle Hongbin Chi
Ning Huang
Huamao Liang
Rong Li
Congrong Liu
Jie Qiao
Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor
Frontiers in Oncology
anti-Mullerian hormone
granulosa cell tumor
hyperandrogenism
infertility
ovarian cyst
author_facet Hongbin Chi
Ning Huang
Huamao Liang
Rong Li
Congrong Liu
Jie Qiao
author_sort Hongbin Chi
title Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor
title_short Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor
title_full Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor
title_fullStr Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor
title_full_unstemmed Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor
title_sort abnormal elevation of anti-mullerian hormone and androgen levels presenting as granulosa cell tumor
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-03-01
description We report a rare subtype of adult cystic granulosa cell tumor (AGCT) characterized by elevated anti-Mullerian hormone and hyperandrogenism. A 35-year-old woman with primary infertility, hyperandrogenism, and irregular menses who was previously diagnosed with polycystic ovarian syndrome was diagnosed with AGCT based on histopathological examination and FOXL2 genetic test after laparoscopy. Due to fertility aspirations, she underwent controlled ovarian stimulation followed by embryo cryopreservation before salpingo-oophorectomy, and two embryos were frozen-thawed and transferred after surgery. A healthy female infant was delivered at 40 weeks’ gestation. Cystic granulosa cell tumors should be considered a differential diagnosis in patients with persistent ovarian cysts and hyperandrogenism. Younger patients with AGCT with fertility goals should consider active assisted reproduction measures to preserve fertility before treatment for AGCT.
topic anti-Mullerian hormone
granulosa cell tumor
hyperandrogenism
infertility
ovarian cyst
url https://www.frontiersin.org/articles/10.3389/fonc.2021.641166/full
work_keys_str_mv AT hongbinchi abnormalelevationofantimullerianhormoneandandrogenlevelspresentingasgranulosacelltumor
AT ninghuang abnormalelevationofantimullerianhormoneandandrogenlevelspresentingasgranulosacelltumor
AT huamaoliang abnormalelevationofantimullerianhormoneandandrogenlevelspresentingasgranulosacelltumor
AT rongli abnormalelevationofantimullerianhormoneandandrogenlevelspresentingasgranulosacelltumor
AT congrongliu abnormalelevationofantimullerianhormoneandandrogenlevelspresentingasgranulosacelltumor
AT jieqiao abnormalelevationofantimullerianhormoneandandrogenlevelspresentingasgranulosacelltumor
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