Peculiarities of epicutaneous action of hexyl ether of 5-aminolevulinic acid

• Main Authors: Е.K. Vlasenko, S.I. Sychik, I.I. Ilyukova, V.А. Stelmakh, V.А. Grynchak
• Format: Article
• Language: English
• Published: FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies” 2015-03-01
• Series: Analiz Riska Zdorovʹû
• Subjects: toxicity; hexyl ether of 5-aminolevulinic acid; epicutaneous impact
• Online Access: http://journal.fcrisk.ru/eng/2015/1/6
• ISSN: 2308-1155; 2308-1163

We studied the subacute toxicity of hexyl ether of 5-aminolevulinic acid at the epicutaneous action in the experiment with white rats. It was established that repeated application of hexyl ether of 5-aminolevulinic acid cause the weak reaction of the white rats skin in the form of edema. The transdermal hexyl ether of 5-aminolevulinic acid intake route is characterized by the increase in the alanine aminotransferase activity, the level of urea in the blood serum and shift to the acid side of pH in the urine of experimental animals. The exposure dose of 341 mg/kg is the dose acting with minimum deviations of values and is accepted as threshold. The exposure dose of 75 mg/kg does not cause the changes in the condition of laboratory animals and is the maximum inactive dose.