Sex-Related Differences in Lactotroph Tumor Aggressiveness Are Associated With a Specific Gene-Expression Signature and Genome Instability

Sex-Related Differences in Lactotroph Tumor Aggressiveness Are Associated With a Specific Gene-Expression Signature and Genome Instability

Sex-related differences have been reported in various cancers, in particular men with lactotroph tumors have a worse prognosis than women. While the underlying mechanism of this sexual dimorphism remains unclear, it has been suggested that a lower estrogen receptor alpha expression may drive the sex...

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Bibliographic Details
Main Authors: Anne Wierinckx, Etienne Delgrange, Philippe Bertolino, Patrick François, Philippe Chanson, Emmanuel Jouanneau, Joël Lachuer, Jacqueline Trouillas, Gérald Raverot
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Endocrinology
Subjects:
pituitary tumors
gene expression
estrogen signaling
sexual dimorphism
chromosome
aggressiveness
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00706/full

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