(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes

Background: Pancreatic Islets of Langerhans are heterogeneous tissues consisting of multiple endocrine cell types that carry out distinct yet coordinated roles to regulate blood glucose homeostasis. Islet dysfunction and specifically failure of the beta cells to secrete adequate insulin are known pr...

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Bibliographic Details
Main Authors: Nathan Lawlor, Michael L. Stitzel
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877819305629