Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime

Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime

We first reported the new application of a translate metal chelating ligand &#945;-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino ac...

Full description

Bibliographic Details
Main Authors: Chunling Yuan, Lei Zhang, Yingdai Zhao
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
α-benzoin oxime
copper catalyst
(hetero)aryl halides
<i>n</i>-nucleophiles
c-n coupling
Online Access:https://www.mdpi.com/1420-3049/24/22/4177
id doaj-716f0cb809264e2e9457bd53327adefb
record_format Article
spelling doaj-716f0cb809264e2e9457bd53327adefb2020-11-25T02:21:51ZengMDPI AGMolecules1420-30492019-11-012422417710.3390/molecules24224177molecules24224177Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin OximeChunling Yuan0Lei Zhang1Yingdai Zhao2Department of Medicinal Chemistry, Pharmacy School, Jinzhou Medical University, Jinzhou 121001, ChinaDepartment of Medicinal Chemistry, Pharmacy School, Jinzhou Medical University, Jinzhou 121001, ChinaDepartment of Medicinal Chemistry, Pharmacy School, Jinzhou Medical University, Jinzhou 121001, ChinaWe first reported the new application of a translate metal chelating ligand &#945;-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaffolds found in FDA-approved pharmaceuticals.https://www.mdpi.com/1420-3049/24/22/4177α-benzoin oximecopper catalyst(hetero)aryl halides<i>n</i>-nucleophilesc-n coupling
collection DOAJ
language English
format Article
sources DOAJ
author Chunling Yuan
Lei Zhang
Yingdai Zhao
spellingShingle Chunling Yuan
Lei Zhang
Yingdai Zhao
Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime
Molecules
α-benzoin oxime
copper catalyst
(hetero)aryl halides
<i>n</i>-nucleophiles
c-n coupling
author_facet Chunling Yuan
Lei Zhang
Yingdai Zhao
author_sort Chunling Yuan
title Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime
title_short Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime
title_full Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime
title_fullStr Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime
title_full_unstemmed Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime
title_sort cu(ii)-catalyzed c-n coupling of (hetero)aryl halides and <i>n</i>-nucleophiles promoted by <i>α</i>-benzoin oxime
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-11-01
description We first reported the new application of a translate metal chelating ligand &#945;-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaffolds found in FDA-approved pharmaceuticals.
topic α-benzoin oxime
copper catalyst
(hetero)aryl halides
<i>n</i>-nucleophiles
c-n coupling
url https://www.mdpi.com/1420-3049/24/22/4177
work_keys_str_mv AT chunlingyuan cuiicatalyzedcncouplingofheteroarylhalidesandininucleophilespromotedbyiaibenzoinoxime
AT leizhang cuiicatalyzedcncouplingofheteroarylhalidesandininucleophilespromotedbyiaibenzoinoxime
AT yingdaizhao cuiicatalyzedcncouplingofheteroarylhalidesandininucleophilespromotedbyiaibenzoinoxime
_version_ 1724865094698926080

Similar Items