GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model

GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model

Fragile X syndrome (FXS), caused by loss of FMR1 gene function, is the most common heritable cause of intellectual disability and autism spectrum disorders. The FMR1 protein (FMRP) translational regulator mediates activity-dependent control of synapses. In addition to the metabotropic glutamate rece...

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Bibliographic Details
Main Authors: Cheryl L. Gatto, Daniel Pereira, Kendal Broadie
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Fragile X mental retardation protein (FMRP)
Mushroom Body
Glutamic acid decarboxylase
Synapse
Calcium signaling
Associative learning
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000151

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http://www.sciencedirect.com/science/article/pii/S0969996114000151

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