Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis

Qing-Tao Zhao,* Tao Guo,* Hui-En Wang,* Xiao-Peng Zhang, Hua Zhang, Zhi-Kang Wang, Zheng Yuan, Guo-Chen Duan Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China *These authors contributed equally to this work Abstract: The dia...

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Main Authors: Zhao QT, Guo T, Wang HE, Zhang XP, Zhang H, Wang ZK, Yuan Z, Duan GC
Format: Article
Language:English
Published: Dove Medical Press 2015-11-01
Series:OncoTargets and Therapy
Online Access:https://www.dovepress.com/diagnostic-value-of-shox2-dna-methylation-in-lung-cancer-a-meta-analys-peer-reviewed-article-OTT
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spelling doaj-716d81774bf34955963088b011c6dd4c2020-11-24T23:18:30ZengDove Medical PressOncoTargets and Therapy1178-69302015-11-012015default3433343924684Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysisZhao QTGuo TWang HEZhang XPZhang HWang ZKYuan ZDuan GCQing-Tao Zhao,* Tao Guo,* Hui-En Wang,* Xiao-Peng Zhang, Hua Zhang, Zhi-Kang Wang, Zheng Yuan, Guo-Chen Duan Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China *These authors contributed equally to this work Abstract: The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46–0.87), SPE =0.96 (95% CI: 0.91–0.99), PLR 20.01 (95% CI: 6.96–57.52), NLR 0.31 (95% CI: 0.15–0.64), and DOR 65.11 (95% CI: 13.10–323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future. Keywords: lung cancer, SHOX2, meta-analysis, diagnostic testhttps://www.dovepress.com/diagnostic-value-of-shox2-dna-methylation-in-lung-cancer-a-meta-analys-peer-reviewed-article-OTT
collection DOAJ
language English
format Article
sources DOAJ
author Zhao QT
Guo T
Wang HE
Zhang XP
Zhang H
Wang ZK
Yuan Z
Duan GC
spellingShingle Zhao QT
Guo T
Wang HE
Zhang XP
Zhang H
Wang ZK
Yuan Z
Duan GC
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
OncoTargets and Therapy
author_facet Zhao QT
Guo T
Wang HE
Zhang XP
Zhang H
Wang ZK
Yuan Z
Duan GC
author_sort Zhao QT
title Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
title_short Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
title_full Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
title_fullStr Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
title_full_unstemmed Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
title_sort diagnostic value of shox2 dna methylation in lung cancer: a meta-analysis
publisher Dove Medical Press
series OncoTargets and Therapy
issn 1178-6930
publishDate 2015-11-01
description Qing-Tao Zhao,* Tao Guo,* Hui-En Wang,* Xiao-Peng Zhang, Hua Zhang, Zhi-Kang Wang, Zheng Yuan, Guo-Chen Duan Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China *These authors contributed equally to this work Abstract: The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46–0.87), SPE =0.96 (95% CI: 0.91–0.99), PLR 20.01 (95% CI: 6.96–57.52), NLR 0.31 (95% CI: 0.15–0.64), and DOR 65.11 (95% CI: 13.10–323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future. Keywords: lung cancer, SHOX2, meta-analysis, diagnostic test
url https://www.dovepress.com/diagnostic-value-of-shox2-dna-methylation-in-lung-cancer-a-meta-analys-peer-reviewed-article-OTT
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