Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
Qing-Tao Zhao,* Tao Guo,* Hui-En Wang,* Xiao-Peng Zhang, Hua Zhang, Zhi-Kang Wang, Zheng Yuan, Guo-Chen Duan Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China *These authors contributed equally to this work Abstract: The dia...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2015-11-01
|
Series: | OncoTargets and Therapy |
Online Access: | https://www.dovepress.com/diagnostic-value-of-shox2-dna-methylation-in-lung-cancer-a-meta-analys-peer-reviewed-article-OTT |
id |
doaj-716d81774bf34955963088b011c6dd4c |
---|---|
record_format |
Article |
spelling |
doaj-716d81774bf34955963088b011c6dd4c2020-11-24T23:18:30ZengDove Medical PressOncoTargets and Therapy1178-69302015-11-012015default3433343924684Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysisZhao QTGuo TWang HEZhang XPZhang HWang ZKYuan ZDuan GCQing-Tao Zhao,* Tao Guo,* Hui-En Wang,* Xiao-Peng Zhang, Hua Zhang, Zhi-Kang Wang, Zheng Yuan, Guo-Chen Duan Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China *These authors contributed equally to this work Abstract: The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46–0.87), SPE =0.96 (95% CI: 0.91–0.99), PLR 20.01 (95% CI: 6.96–57.52), NLR 0.31 (95% CI: 0.15–0.64), and DOR 65.11 (95% CI: 13.10–323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future. Keywords: lung cancer, SHOX2, meta-analysis, diagnostic testhttps://www.dovepress.com/diagnostic-value-of-shox2-dna-methylation-in-lung-cancer-a-meta-analys-peer-reviewed-article-OTT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhao QT Guo T Wang HE Zhang XP Zhang H Wang ZK Yuan Z Duan GC |
spellingShingle |
Zhao QT Guo T Wang HE Zhang XP Zhang H Wang ZK Yuan Z Duan GC Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis OncoTargets and Therapy |
author_facet |
Zhao QT Guo T Wang HE Zhang XP Zhang H Wang ZK Yuan Z Duan GC |
author_sort |
Zhao QT |
title |
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_short |
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_full |
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_fullStr |
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_full_unstemmed |
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_sort |
diagnostic value of shox2 dna methylation in lung cancer: a meta-analysis |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2015-11-01 |
description |
Qing-Tao Zhao,* Tao Guo,* Hui-En Wang,* Xiao-Peng Zhang, Hua Zhang, Zhi-Kang Wang, Zheng Yuan, Guo-Chen Duan Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China *These authors contributed equally to this work Abstract: The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46–0.87), SPE =0.96 (95% CI: 0.91–0.99), PLR 20.01 (95% CI: 6.96–57.52), NLR 0.31 (95% CI: 0.15–0.64), and DOR 65.11 (95% CI: 13.10–323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future. Keywords: lung cancer, SHOX2, meta-analysis, diagnostic test |
url |
https://www.dovepress.com/diagnostic-value-of-shox2-dna-methylation-in-lung-cancer-a-meta-analys-peer-reviewed-article-OTT |
work_keys_str_mv |
AT zhaoqt diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT guot diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT wanghe diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT zhangxp diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT zhangh diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT wangzk diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT yuanz diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis AT duangc diagnosticvalueofshox2dnamethylationinlungcancerametaanalysis |
_version_ |
1725581253730631680 |