Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid

Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid

Background: In Alzheimer’s disease (AD) neuronal degeneration is associated with gliosis and infiltration of peripheral blood mononuclear cells (PBMCs), which participate in neuroinflammation. Defects at the blood-brain barrier (BBB) facilitate PBMCs migration towards the central nervous system (CNS...

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Bibliographic Details
Main Authors: Simona Federica Spampinato, Sara Merlo, Evelina Fagone, Mary Fruciano, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
BBB
Th2
IL-4
BDNF
synaptophysin
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00120/full

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