Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen f...

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Main Authors: Eman Y. Z. Frag, Gehad G. Mohamed, Mohamed M. Khalil, Mohammad M. A. Hwehy
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Analytical Chemistry
Online Access:http://dx.doi.org/10.1155/2011/604741
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spelling doaj-7161f1d112ae48d4a0299bb5626fd49b2020-11-24T22:34:27ZengHindawi LimitedInternational Journal of Analytical Chemistry1687-87601687-87792011-01-01201110.1155/2011/604741604741Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective ElectrodesEman Y. Z. Frag0Gehad G. Mohamed1Mohamed M. Khalil2Mohammad M. A. Hwehy3Chemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Beni Suef University, Beni Suef, EgyptChemistry Department, Faculty of Science, Beni Suef University, Beni Suef, EgyptThis study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7 to 10−2 mol L−1. The electrodes show Nernstian slope value of 52.51±0.20 and 51.51±0.25 mV decade−1 for CPE and PVC membrane electrodes at 30∘C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.http://dx.doi.org/10.1155/2011/604741
collection DOAJ
language English
format Article
sources DOAJ
author Eman Y. Z. Frag
Gehad G. Mohamed
Mohamed M. Khalil
Mohammad M. A. Hwehy
spellingShingle Eman Y. Z. Frag
Gehad G. Mohamed
Mohamed M. Khalil
Mohammad M. A. Hwehy
Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
International Journal of Analytical Chemistry
author_facet Eman Y. Z. Frag
Gehad G. Mohamed
Mohamed M. Khalil
Mohammad M. A. Hwehy
author_sort Eman Y. Z. Frag
title Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
title_short Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
title_full Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
title_fullStr Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
title_full_unstemmed Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
title_sort potentiometric determination of ketotifen fumarate in pharmaceutical preparations and urine using carbon paste and pvc membrane selective electrodes
publisher Hindawi Limited
series International Journal of Analytical Chemistry
issn 1687-8760
1687-8779
publishDate 2011-01-01
description This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7 to 10−2 mol L−1. The electrodes show Nernstian slope value of 52.51±0.20 and 51.51±0.25 mV decade−1 for CPE and PVC membrane electrodes at 30∘C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.
url http://dx.doi.org/10.1155/2011/604741
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