Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen f...
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doaj-7161f1d112ae48d4a0299bb5626fd49b2020-11-24T22:34:27ZengHindawi LimitedInternational Journal of Analytical Chemistry1687-87601687-87792011-01-01201110.1155/2011/604741604741Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective ElectrodesEman Y. Z. Frag0Gehad G. Mohamed1Mohamed M. Khalil2Mohammad M. A. Hwehy3Chemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Beni Suef University, Beni Suef, EgyptChemistry Department, Faculty of Science, Beni Suef University, Beni Suef, EgyptThis study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7 to 10−2 mol L−1. The electrodes show Nernstian slope value of 52.51±0.20 and 51.51±0.25 mV decade−1 for CPE and PVC membrane electrodes at 30∘C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.http://dx.doi.org/10.1155/2011/604741 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eman Y. Z. Frag Gehad G. Mohamed Mohamed M. Khalil Mohammad M. A. Hwehy |
spellingShingle |
Eman Y. Z. Frag Gehad G. Mohamed Mohamed M. Khalil Mohammad M. A. Hwehy Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes International Journal of Analytical Chemistry |
author_facet |
Eman Y. Z. Frag Gehad G. Mohamed Mohamed M. Khalil Mohammad M. A. Hwehy |
author_sort |
Eman Y. Z. Frag |
title |
Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes |
title_short |
Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes |
title_full |
Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes |
title_fullStr |
Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes |
title_full_unstemmed |
Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes |
title_sort |
potentiometric determination of ketotifen fumarate in pharmaceutical preparations and urine using carbon paste and pvc membrane selective electrodes |
publisher |
Hindawi Limited |
series |
International Journal of Analytical Chemistry |
issn |
1687-8760 1687-8779 |
publishDate |
2011-01-01 |
description |
This study compares
between unmodified carbon paste (CPE; the paste
has no ion pair) and polyvinyl chloride (PVC)
membrane selective electrodes that were used in
potentiometric determination of ketotifen
fumarate (KTF), where sodium tetraphenylborate
(NaTPB) was used as titrant. The performance
characteristics of these sensors were evaluated
according to IUPAC recommendations which reveal
a fast, stable, and linear response for KTF over
the concentration range of 10−7 to
10−2 mol L−1. The
electrodes show Nernstian slope value of
52.51±0.20 and 51.51±0.25 mV decade−1 for CPE and PVC membrane
electrodes at 30∘C, respectively. The potential
is nearly stable over the pH range 3.0–6.0 and 2.0–7.0
for CPE and PVC membrane electrodes, respectively. Selectivity
coefficient values towards different inorganic cations, sugars, and
amino acids reflect high selectivity of the prepared electrodes.
The electrodes responses at different temperatures were also
studied, and long operational lifetime of 12 and 5 weeks for CPE
and PVC membrane electrodes, respectively, were found. These are
used for determination of ketotifen fumarate using potentiometric
titration, calibration, and standard addition methods in pure
samples, its pharmaceutical preparations (Zaditen tablets), and
biological fluid (urine). The direct potentiometric determination
of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method. |
url |
http://dx.doi.org/10.1155/2011/604741 |
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