Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae

Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae

Resistance in Neisseria gonorrhoeae to all available therapeutic antimicrobials has emerged and new efficacious drugs for treatment of gonorrhea are essential. The topoisomerase II inhibitor ETX0914 (also known as AZD0914) is a new spiropyrimidinetrione antimicrobial that has different mechanisms of...

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Bibliographic Details
Main Authors: Sunniva eFoerster, Daniel eGolparian, Susanne eJacobsson, Lucy eHathaway, Nicola eLow, William eShafer, Christian eAlthaus, Magnus eUnemo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Microbiology
Subjects:
Gonorrhea
Treatment
Pharmacodynamics
antimicrobial resistance
time-kill curve analysis
DNA topoisomerase II inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01377/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01377/full

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