Virulence genome analysis of Pseudomonas aeruginosa VRFPA10 recovered from patient with scleritis

• Main Authors: Nandagopal Murugan, Jambulingam Malathi, Vetrivel Umashankar, Hajib Narahari Rao Madhavan
• Format: Article
• Language: English
• Published: Elsevier 2017-06-01
• Series: Genomics Data
• Subjects: Pseudomonas aeruginosa; Virulence; Drug resistance; Genomics; Next generation sequencing; Scleritis; Ocular infection
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213596017300016

Infectious keratitis is a major cause of blindness, next to cataract and majority of cases are mainly caused by gram negative bacterium Pseudomonas aeruginosa (P. aeruginosa). In this study, we investigated a P. aeruginosa VRFPA10 genome which exhibited susceptibility to commonly used drugs in vitro but the patient had poor prognosis due to its hyper virulent nature. Genomic analysis of VRFPA10 deciphered multiple virulence factors and P.aeruginosa Genomic Islands (PAGIs) VRFPA10 genome which correlated with hyper virulence nature of the organism. The genome sequence has been deposited in DDBJ/EMBL/GenBank under the accession numbers LFMZ01000001-LFMZ01000044.