Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.

Defining the most penetrating correlates of protective memory T cells is key for designing improved vaccines and T cell therapies. Here, we evaluate how interleukin (IL-2) production by memory CD4 T cells, a widely held indicator of their protective potential, impacts immune responses against murine...

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Bibliographic Details
Main Authors: K Kai McKinstry, Fahmida Alam, Valeria Flores-Malavet, Mate Z Nagy, Stewart Sell, Andrea M Cooper, Susan L Swain, Tara M Strutt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007989

Internet

https://doi.org/10.1371/journal.ppat.1007989

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