Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects

• Main Authors: Yi Cai, Rajiv D. Reddy, Vishal Varshney, Krishnan V. Chakravarthy
• Format: Article
• Language: English
• Published: BMC 2020-03-01
• Series: Bioelectronic Medicine
• Subjects: Neuromodulation; Spinal cord stimulation; Parkinson’s disease; Gait; Salvage therapy
• Online Access: http://link.springer.com/article/10.1186/s42234-020-00041-9

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms include tremor, bradykinesia, rigidity, pain, and postural instability, with significant impact in quality of life and mortality. To date there is ongoing research to determine the optimum therapy for PD. In this review we analyze the current data in the use of spinal cord stimulation (SCS) therapy for treatment for Parkinsonian symptoms. We specifically address waveform pattern, anatomic location and the role of spinal cord stimulation (SCS) as a salvage therapy after deep brain stimulation (DBS) therapy. We also outline current experimental evidence from preclinical research highlighting possible mechanisms of beneficial effects of SCS in this context. Though the use of SCS therapy is in its infancy for treatment of PD, the data points to an exciting area for ongoing research and exploration with positive outcomes from both cervical and thoracic tonic and BURSTDR spinal cord stimulation.