A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
Abstract Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well anal...
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BMC
2019-11-01
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| Series: | BMC Chemistry |
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| Online Access: | http://link.springer.com/article/10.1186/s13065-019-0651-2 |
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doaj-71391ef389ce4bad9796002eb356af2f2020-11-25T01:08:44ZengBMCBMC Chemistry2661-801X2019-11-011311710.1186/s13065-019-0651-2A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiationMandlenkosi Robert Khumalo0Surya Narayana Maddila1Suresh Maddila2Sreekantha B. Jonnalagadda3School of Chemistry & Physics, University of KwaZulu-NatalSchool of Chemistry & Physics, University of KwaZulu-NatalSchool of Chemistry & Physics, University of KwaZulu-NatalSchool of Chemistry & Physics, University of KwaZulu-NatalAbstract Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (1H NMR, 13C NMR, 15N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup.http://link.springer.com/article/10.1186/s13065-019-0651-2Microwave irradiationMulticomponent reactionsOne-pot synthesisGreen synthesisBenzopyrans |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mandlenkosi Robert Khumalo Surya Narayana Maddila Suresh Maddila Sreekantha B. Jonnalagadda |
| spellingShingle |
Mandlenkosi Robert Khumalo Surya Narayana Maddila Suresh Maddila Sreekantha B. Jonnalagadda A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation BMC Chemistry Microwave irradiation Multicomponent reactions One-pot synthesis Green synthesis Benzopyrans |
| author_facet |
Mandlenkosi Robert Khumalo Surya Narayana Maddila Suresh Maddila Sreekantha B. Jonnalagadda |
| author_sort |
Mandlenkosi Robert Khumalo |
| title |
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation |
| title_short |
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation |
| title_full |
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation |
| title_fullStr |
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation |
| title_full_unstemmed |
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation |
| title_sort |
facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation |
| publisher |
BMC |
| series |
BMC Chemistry |
| issn |
2661-801X |
| publishDate |
2019-11-01 |
| description |
Abstract Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (1H NMR, 13C NMR, 15N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup. |
| topic |
Microwave irradiation Multicomponent reactions One-pot synthesis Green synthesis Benzopyrans |
| url |
http://link.springer.com/article/10.1186/s13065-019-0651-2 |
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