How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians

How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians

A match of HLA loci between patients and donors is critical for successful hematopoietic stem cell transplantation. However, the extreme polymorphism of HLA loci – an outcome of millions of years of natural selection – reduces the chances that two individuals will carry identical combinations of mul...

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Bibliographic Details
Main Authors: Kelly Nunes, Vitor R. C. Aguiar, Márcio Silva, Alexandre C. Sena, Danielli C. M. de Oliveira, Carla L. Dinardo, Fernanda S. G. Kehdy, Eduardo Tarazona-Santos, Vanderson G. Rocha, Anna Barbara F. Carneiro-Proietti, Paula Loureiro, Miriam V. Flor-Park, Claudia Maximo, Shannon Kelly, Brian Custer, Bruce S. Weir, Ester C. Sabino, Luís Cristóvão Porto, Diogo Meyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
HLA
hematopoietic stem cell transplantation
genetic ancestry
admixture
MHC
Brazil
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.584950/full

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