Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a major regulator of the oxidative stress response and it is negatively regulated by Kelch-like ECH-associated protein 1 (Keap1). The Keap1–Nrf2 axis has a fundamental role in carcinogenesis. In previous studies, the widely used diabetes drug met...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2019-01-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428318815413 |