Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update

Bisphosphonates are a synthetic class of pyrophosphate analogues that are powerful inhibitors of bone resorption which are commonly used as a medication for the prevention and therapy of osteoporosis and osteopenia, also used to treat tumor diseases. As it affects bone metabolism, it is said to ha...

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Main Authors: Sindhuja Krishnan, Saravana Pandian, Aravind Kumar. S
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2015-04-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/5769/11162_CE(Ra1)_F(GH)_PF1(NJAK)_PFA(AK)_PFA2(AK)_PF2(PAG).pdf
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spelling doaj-712d2cbfdbd94fa5a6755edb88a40ca02020-11-25T03:39:28ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-04-0194ZE01ZE0510.7860/JCDR/2015/11162.5769Effect of Bisphosphonates on Orthodontic Tooth Movement—An UpdateSindhuja Krishnan0Saravana Pandian1Aravind Kumar. S2Post Graduation, Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College, Saveetha, University, Chennai, Tamilnadu, India.Post Graduation, Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College, Saveetha, University, Chennai, Tamilnadu, India. Professor, Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College, Saveetha, University, Chennai, Tamilnadu, India. Bisphosphonates are a synthetic class of pyrophosphate analogues that are powerful inhibitors of bone resorption which are commonly used as a medication for the prevention and therapy of osteoporosis and osteopenia, also used to treat tumor diseases. As it affects bone metabolism, it is said to have an influence on orthodontic treatment and tooth movement. Also, this review gives an insight into the reported effects of Bisphosphonate medication in literature highlighting the status quo of scientific research regarding effects of Bisphosphonates on orthodontic tooth movement. A systematic literature search was done in Medline database (Pubmed) for the appropriate keywords. Manual handsearch was also done. From the available evidence it can be concluded that the duration of orthodontic treatment is increased for patients under Bisphosphonate therapy as they interfere with the osteoclastic resorption. However, they may be beneficial for anchorage procedures. Further long term prospective randomized controlled trials are required to assess possible benefits and adverse effects of bisphosphonate treatment, before Bisphosphonates can be therapeutically used in orthodontics.https://jcdr.net/articles/PDF/5769/11162_CE(Ra1)_F(GH)_PF1(NJAK)_PFA(AK)_PFA2(AK)_PF2(PAG).pdfbisphosphonatesorthodontic tooth movementorthodontic anchorageroot resorption
collection DOAJ
language English
format Article
sources DOAJ
author Sindhuja Krishnan
Saravana Pandian
Aravind Kumar. S
spellingShingle Sindhuja Krishnan
Saravana Pandian
Aravind Kumar. S
Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update
Journal of Clinical and Diagnostic Research
bisphosphonates
orthodontic tooth movement
orthodontic anchorage
root resorption
author_facet Sindhuja Krishnan
Saravana Pandian
Aravind Kumar. S
author_sort Sindhuja Krishnan
title Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update
title_short Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update
title_full Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update
title_fullStr Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update
title_full_unstemmed Effect of Bisphosphonates on Orthodontic Tooth Movement—An Update
title_sort effect of bisphosphonates on orthodontic tooth movement—an update
publisher JCDR Research and Publications Private Limited
series Journal of Clinical and Diagnostic Research
issn 2249-782X
0973-709X
publishDate 2015-04-01
description Bisphosphonates are a synthetic class of pyrophosphate analogues that are powerful inhibitors of bone resorption which are commonly used as a medication for the prevention and therapy of osteoporosis and osteopenia, also used to treat tumor diseases. As it affects bone metabolism, it is said to have an influence on orthodontic treatment and tooth movement. Also, this review gives an insight into the reported effects of Bisphosphonate medication in literature highlighting the status quo of scientific research regarding effects of Bisphosphonates on orthodontic tooth movement. A systematic literature search was done in Medline database (Pubmed) for the appropriate keywords. Manual handsearch was also done. From the available evidence it can be concluded that the duration of orthodontic treatment is increased for patients under Bisphosphonate therapy as they interfere with the osteoclastic resorption. However, they may be beneficial for anchorage procedures. Further long term prospective randomized controlled trials are required to assess possible benefits and adverse effects of bisphosphonate treatment, before Bisphosphonates can be therapeutically used in orthodontics.
topic bisphosphonates
orthodontic tooth movement
orthodontic anchorage
root resorption
url https://jcdr.net/articles/PDF/5769/11162_CE(Ra1)_F(GH)_PF1(NJAK)_PFA(AK)_PFA2(AK)_PF2(PAG).pdf
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