Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma

Abstract Monocarboxylate transporter‐4 (MCT4), a monocarboxylic acid transporter, demonstrates significantly increased expression in the majority of malignancies. We performed an experiment using BALB/C mice, and our results showed that ShMCT4 transfection or the pharmaceutic inhibition of MCT4 with...

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Bibliographic Details
Main Authors: Yaping Long, Zihe Gao, Xiao Hu, Feng Xiang, Zhaozhen Wu, Jiahui Zhang, Xiao Han, Liyong Yin, Junfang Qin, Lan Lan, Fuzai Yin, Yue Wang
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Cancer Medicine
Subjects:
Online Access:https://doi.org/10.1002/cam4.1713