Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma

Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma

Background: Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma. Previous preclinical data from our group demonstrated the anti-myeloma effect of the pan-PIM kinase inhibitor PIM447. Methods: Based on those...

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Bibliographic Details
Main Authors: Teresa Paíno, Lorena González-Méndez, Laura San-Segundo, Luis A. Corchete, Susana Hernández-García, Andrea Díaz-Tejedor, Esperanza M. Algarín, Pedro Mogollón, Montserrat Martín-Sánchez, Norma C. Gutiérrez, María-Victoria Mateos, Mercedes Garayoa, Enrique M. Ocio
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
multiple myeloma
pan-PIM kinase inhibitor
drug combination
protein translation
Online Access:https://www.mdpi.com/2072-6694/12/10/2743

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