Rhabdomyolysis and autoimmune variant stiff-person syndrome

Rhabdomyolysis and autoimmune variant stiff-person syndrome

Stiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge n...

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Main Authors: Shreyas Gangadhara, Suhas Gangadhara, Chetan Gandhy, Derrick Robertson
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Clinics and Practice
Subjects:
Stiff-person syndrome
rhabdomyolysis
spasms.
Online Access:https://www.clinicsandpractice.org/index.php/cp/article/view/885
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spelling doaj-70f68a372df74e4486f9a1f524cecefc2021-04-02T11:06:23ZengMDPI AGClinics and Practice2039-72752039-72832016-11-016410.4081/cp.2016.885364Rhabdomyolysis and autoimmune variant stiff-person syndromeShreyas Gangadhara0Suhas Gangadhara1Chetan Gandhy2Derrick Robertson3Division of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FLDivision of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FLDivision of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FL; Department of Neurology, James A Haley Veterans Hospital, Tampa, FLDivision of Vascular Neurology, Department of Neurology, University of South Florida, Morsani College of Medicine, Tampa, FLStiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge no case has been reported involving the autoimmune variant. We report a case report of a 50-year-old man with history of SPS who presented with recurrent episodes of severe limb and back spasms. He was hospitalized on two separate occasions for uncontrollable spasms associated with renal failure and creatinine phosphokinase elevations of 55,000 and 22,000 U/L respectively. Laboratory tests were otherwise unremarkable. The acute renal failure resolved during both admissions with supportive management. Rhabdomyolysis has the potential to be fatal and early diagnosis is essential. It should be considered in patients who have SPS and are experiencing an exacerbation of their neurologic condition.https://www.clinicsandpractice.org/index.php/cp/article/view/885Stiff-person syndromerhabdomyolysisspasms.
collection DOAJ
language English
format Article
sources DOAJ
author Shreyas Gangadhara
Suhas Gangadhara
Chetan Gandhy
Derrick Robertson
spellingShingle Shreyas Gangadhara
Suhas Gangadhara
Chetan Gandhy
Derrick Robertson
Rhabdomyolysis and autoimmune variant stiff-person syndrome
Clinics and Practice
Stiff-person syndrome
rhabdomyolysis
spasms.
author_facet Shreyas Gangadhara
Suhas Gangadhara
Chetan Gandhy
Derrick Robertson
author_sort Shreyas Gangadhara
title Rhabdomyolysis and autoimmune variant stiff-person syndrome
title_short Rhabdomyolysis and autoimmune variant stiff-person syndrome
title_full Rhabdomyolysis and autoimmune variant stiff-person syndrome
title_fullStr Rhabdomyolysis and autoimmune variant stiff-person syndrome
title_full_unstemmed Rhabdomyolysis and autoimmune variant stiff-person syndrome
title_sort rhabdomyolysis and autoimmune variant stiff-person syndrome
publisher MDPI AG
series Clinics and Practice
issn 2039-7275
2039-7283
publishDate 2016-11-01
description Stiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge no case has been reported involving the autoimmune variant. We report a case report of a 50-year-old man with history of SPS who presented with recurrent episodes of severe limb and back spasms. He was hospitalized on two separate occasions for uncontrollable spasms associated with renal failure and creatinine phosphokinase elevations of 55,000 and 22,000 U/L respectively. Laboratory tests were otherwise unremarkable. The acute renal failure resolved during both admissions with supportive management. Rhabdomyolysis has the potential to be fatal and early diagnosis is essential. It should be considered in patients who have SPS and are experiencing an exacerbation of their neurologic condition.
topic Stiff-person syndrome
rhabdomyolysis
spasms.
url https://www.clinicsandpractice.org/index.php/cp/article/view/885
work_keys_str_mv AT shreyasgangadhara rhabdomyolysisandautoimmunevariantstiffpersonsyndrome
AT suhasgangadhara rhabdomyolysisandautoimmunevariantstiffpersonsyndrome
AT chetangandhy rhabdomyolysisandautoimmunevariantstiffpersonsyndrome
AT derrickrobertson rhabdomyolysisandautoimmunevariantstiffpersonsyndrome
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