Mrc1-Dependent Chromatin Compaction Represses DNA Double-Stranded Break Repair by Homologous Recombination Upon Replication Stress

Mrc1-Dependent Chromatin Compaction Represses DNA Double-Stranded Break Repair by Homologous Recombination Upon Replication Stress

The coordination of DNA replication and repair is critical for the maintenance of genome stability. It has been shown that the Mrc1-mediated S phase checkpoint inhibits DNA double-stranded break (DSB) repair through homologous recombination (HR). How the replication checkpoint inhibits HR remains on...

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Bibliographic Details
Main Authors: Poyuan Xing, Yang Dong, Jingyu Zhao, Zhou Zhou, Zhao Li, Yu Wang, Mengfei Li, Xinghua Zhang, Xuefeng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
replication checkpoint
Mrc1
DNA double-stranded breaks
homologous recombination
replication stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.630777/full

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