The effectiveness of ulcerative colitis treatment depending on the route of medical drug usage

• Main Author: V. O. Petryna
• Format: Article
• Language: English
• Published: Zaporozhye State Medical University 2017-08-01
• Series: Zaporožskij Medicinskij Žurnal
• Subjects: ulcerative colitis; dysbiosis; dysbacteriosis intestinal; therapeutics
• Online Access: http://zmj.zsmu.edu.ua/article/view/105030/101288
• ISSN: 2306-4145; 2310-1210

Aim to increase the effectiveness of ulcerative colitis (UC) treatment by combination of the basic therapy with Bifidumbacterin in microclysters with clinical and pathogenic features of the disease assessment. Materials and methods. 38 UC patients with primary lesion of the left side colon (20 men, 18 women) in the disease active phase were recruited into the study. The average age was 32.4 ± 8.1 years with disease duration from 1 to 10 years. All patients were divided into 2 equal groups: Group I consisted of patients who were prescribed basic therapy with common scheme, and the second group – patients with basic therapy, who received 10 additional doses of Bifidumbacterin in microclysters (once daily for 14 days). Common clinical, laboratory, endoscopy (colonoscopy, sigmoidoscopy), morphological (histological examination of biopsy), bacteriological (intestinal microbiota) and statistical methods were used. Results. Examination of UC patients before and after the course of treatment with Bifidumbacterin in microclysters in combination with basic therapy revealed the positive effect on clinical and endoscopic disease manifestations and restore the colon microflora. The combination of basic UC therapy and Bifidumbacterin in microclysters is efficient enough to achieve and maintain remission, to reduce inflammation of the colon mucous membrane and to correct dysbiosis. Conclusions. Defects of epithelial surface with diffuse inflammatory cell infiltrate of the lamina propria, change of microbiota and marked decrease in the number of obligate microflora with increase the number of elective bacteria were detected. Combination of the basic treatment with Bifidumbacterin in microclysters led to positive dynamics of clinical and endoscopic UC signs. Such as reduction of dysbiosis (the significant increase in the number of bifidobacteria from (5.38 ± 0.17) to (6.79 ± 0.12) lg CFU/g, p < 0.05). Clinical remission in patients of this group was achieved in 73.6 % of cases.