Oncolytic Herpes Simplex Virus-based Strategies: Toward a Breakthrough in Glioblastoma Therapy

Oncolytic Herpes Simplex Virus-based Strategies: Toward a Breakthrough in Glioblastoma Therapy

Oncolytic viruses are a class of antitumor agents that selectively kill tumor cells while sparing normal cells. Oncolytic herpes simplex virus (oHSV) has been investigated in clinical trials for patients with the malignant brain tumor glioblastoma for more than a decade. These clinical studies have...

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Bibliographic Details
Main Authors: Jianfang eNing, Hiroaki eWakimoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Microbiology
Subjects:
Gene Therapy
Glioblastoma
Molecular Targeted Therapy
combination therapy
oncolytic virus
Synergy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00303/full

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