Challenges and Opportunities for Small Molecule Aptamer Development

Challenges and Opportunities for Small Molecule Aptamer Development

Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small...

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Main Authors: Maureen McKeague, Maria C. DeRosa
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.1155/2012/748913
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spelling doaj-70b2542355dc4af3beae50b8fb842cb12020-11-25T00:55:48ZengHindawi LimitedJournal of Nucleic Acids2090-02012090-021X2012-01-01201210.1155/2012/748913748913Challenges and Opportunities for Small Molecule Aptamer DevelopmentMaureen McKeague0Maria C. DeRosa1Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, CanadaDepartment of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, CanadaAptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.http://dx.doi.org/10.1155/2012/748913
collection DOAJ
language English
format Article
sources DOAJ
author Maureen McKeague
Maria C. DeRosa
spellingShingle Maureen McKeague
Maria C. DeRosa
Challenges and Opportunities for Small Molecule Aptamer Development
Journal of Nucleic Acids
author_facet Maureen McKeague
Maria C. DeRosa
author_sort Maureen McKeague
title Challenges and Opportunities for Small Molecule Aptamer Development
title_short Challenges and Opportunities for Small Molecule Aptamer Development
title_full Challenges and Opportunities for Small Molecule Aptamer Development
title_fullStr Challenges and Opportunities for Small Molecule Aptamer Development
title_full_unstemmed Challenges and Opportunities for Small Molecule Aptamer Development
title_sort challenges and opportunities for small molecule aptamer development
publisher Hindawi Limited
series Journal of Nucleic Acids
issn 2090-0201
2090-021X
publishDate 2012-01-01
description Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.
url http://dx.doi.org/10.1155/2012/748913
work_keys_str_mv AT maureenmckeague challengesandopportunitiesforsmallmoleculeaptamerdevelopment
AT mariacderosa challengesandopportunitiesforsmallmoleculeaptamerdevelopment
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