Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture

Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture

Intervertebral disc degeneration is characterized by a cascade of cellular, biochemical and structural changes that may lead to functional impairment and low back pain. Interleukin-1 beta (IL-1β) is strongly implicated in the etiology of disc degeneration, however there is currently no direct eviden...

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Bibliographic Details
Main Authors: LJ Smith, JA Chiaro, NL Nerurkar, DH Cortes, SD Horava, NM Hebela, RL Mauck, GR Dodge, DM Elliott
Format: Article
Language:English
Published: AO Research Institute Davos 2011-11-01
Series:European Cells & Materials
Subjects:
Intervertebral disc
nucleus pulposus
agarose
interleukin-1 beta
interleukin-1 receptor antagonist
biomechanical properties
Online Access:http://www.ecmjournal.org/journal/papers/vol022/pdf/v022a22.pdf

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