Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients

Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients

(1) Background: It is known that sickle cells contain a higher amount of Ca<sup>2+</sup> compared to healthy red blood cells (RBCs). The increased Ca<sup>2+</sup> is associated with the most severe symptom of sickle cell disease (SCD), the vaso-occlusive crisis (VOC). The Ca&...

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Bibliographic Details
Main Authors:	Jue Wang, Laura Hertz, Sandra Ruppenthal, Wassim El Nemer, Philippe Connes, Jeroen S. Goede, Anna Bogdanova, Lutz Birnbaumer, Lars Kaestner
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Cells
Subjects:	erythrocytes sickle cell disease LPA receptor G protein signaling transgenic mice protein kinase Cα
Online Access:	https://www.mdpi.com/2073-4409/10/2/456

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